Phellinstatin, a new inhibitor of enoyl-ACP reductase produced by the medicinal fungus Phellinus linteus

Jun-Young Cho; Yun-Ju Kwon; Mi-Jin Sohn; Soon-Ja Seok; Won-Gon Kim

doi:10.1016/j.bmcl.2011.01.080

Phellinstatin, a new inhibitor of enoyl-ACP reductase produced by the medicinal fungus Phellinus linteus

Bioorg Med Chem Lett. 2011 Mar 15;21(6):1716-8. doi: 10.1016/j.bmcl.2011.01.080. Epub 2011 Jan 22.

Authors

Jun-Young Cho¹, Yun-Ju Kwon, Mi-Jin Sohn, Soon-Ja Seok, Won-Gon Kim

Affiliation

¹ Korea Research Institute of Bioscience and Biotechnology, Yusong, Daejeon, Republic of Korea.

PMID: 21316961
DOI: 10.1016/j.bmcl.2011.01.080

Abstract

A new trimeric hispidin derivative, phellinstatin, was isolated from a culture broth of the medicinal fungus Phellinus linteus and its structure was established by various spectral analysis. Phellinstatin strongly inhibited Staphylococcus aureus enoyl-ACP reductase with an IC(50) of 6 μM and also showed antibacterial activity against S. aureus and MRSA.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catechols / pharmacology*
Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)
Enzyme Inhibitors / pharmacology*
Fungi / enzymology*
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy
Pyrones / pharmacology*
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Infrared

Substances

Catechols
Enzyme Inhibitors
Pyrones
phellinstatin
Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)